Nanoparticles Remodel Oral Connective Tissue, Replace Surgical Blades in Oral Surgery


Photo By  jarmoluk via Pixabay


Israeli researchers have engineered nanoparticles to replace surgical blades used in oral surgery, making a trip to the orthodontist or dentist less fearful for patients.

Recognizing in the abstract of their study, most patients fear the idea of oral surgery because of a painful recovery and the cost of the procedure, the team conducted a pre-clinical study that shows how nanotechnology can potentially lessen the recovery time and pain in oral surgery.

The researchers said that one of the common tools used by an orthodontist or dentist is the surgical blades. These blades, however, cannot distinguish between the diseased or healthy tissue, thereby making unnecessary damage during the surgery. It also means that recovery time lengthens. Not to mention that it also increases the pain that a patient feels, said the team. 

“Through the combination of nanotechnology and proteolytic enzymes, localized surgical procedures can now be less invasive,” wrote the researchers.

To replace the use of a surgical blade, they suggest surgical produces that rely more on the natural tissue tools, the enzymes. Using their engineered nanoparticles that have the deactivated form of collagenase, they put it at the surgical site and was activated by calcium. This led to a supported hard and soft tissue recovery through natural tissue repair mechanism. 

The authors are from Technion−Israel Institute of Technology, Rambam Medical Center, Moriah Animal Companion Center, and Moriah Animal Companion Center.